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Home >> Antibodies >> Mammaglobin (SCGB2A2) (Breast Cancer Marker)

Mammaglobin (SCGB2A2) (Breast Cancer Marker)

Mouse Monoclonal Antibody [Clone SPM518]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Monospecific Mouse Monoclonal Antibody (SPM518) to Mammaglobin.

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SDS-PAGE Analysis of Purified Monospecific Mouse Monoclonal Antibody (SPM518) to Mammaglobin. Confirmation of purity and integrity.

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Western Blot Analysis of Human MCF-7,T47D and MDA-231 cell lysate using Monospecific Mouse Monoclonal Antibody (SPM518) to Mammaglobin.

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Analysis of Protein Array containing >19,000 full-length human proteins using Mammaglobin (SCGB2A2) Mouse Monoclonal Antibody (SPM518)

Product Details

Synonyms

Mammaglobin-1 (MGB1); Mammaglobin-A; Secretoglobin family 2A member 2 (SCGB2A2); SG2A2; UGB2

Positive Control

HeLa or MCF-7 cells. Mammary gland specific. Overexpressed in breast cancer.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human Mammaglobin (SCGB2A2) protein

Cellular Localization

Cytoplasmic, Cell Surface and Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

18kDa

Specificity & Comments

Mammaglobin is a 93 amino acid glycoprotein with homology to other secretoglobin-uteroglobin family members. It was originally identified as a breast cancer restricted biomarker by differential screening. Mammaglobin related to secretoglobin family that includes human uteroglobin and lipophilin. Mammaglobin antibody stains cytoplasm of normal breast epithelial cells as well as primary and metastatic breast carcinomas. Mammaglobin expression is absent in prostate, kidney, colon, rectum, small intestine, stomach, pancreas, lung, and thyroid tissues.Mammaglobin may be used as part of an immunohistochemical panel for determination of metastatic breast carcinoma and tumor of unknown primary origin.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Watson MA, Dintzis S, Darrow CM, Voss LE, DiPersio J, Jensen R, Fleming TP. Mammaglobin expression in primary, metastatic, and occult breast cancer. Cancer Res. 1999;59:3028-3031.

Bioinformatics

  •  Entrez Gene ID: 4250
  •  Gene Symbol: SCGB2A2
  •  SwissProt: Q13296
  •  Chromosome Location: 11q12.3
  •  Unigene: 46452
NBT02000