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Home >> Antibodies >> Lymphocyte Specific Protein 1 (LSP1) / pp52

Lymphocyte Specific Protein 1 (LSP1) / pp52

Mouse Monoclonal Antibody [Clone LSP1/3042]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified Monospecific Mouse Monoclonal Antibody to LSP1 (LSP1/3042). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using LSP1 Mouse Monoclonal Antibody (LSP1/3042).

Product Details

Synonyms

WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1

Positive Control

Human tonsil, colon, spleen or Hodgkin's lymphoma (IHC-P).

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order antibody without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)

Cellular Localization

Membrane.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

52kDa

Specificity & Comments

LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Pulford K., et al. Immunology. 1999 Feb;96(2):262-71.
  2. Zhang H., et al. FEBS Open Bio. 2016 Nov 7;6(12):1227-1237.

Bioinformatics

  •  Entrez Gene ID: 4046
  •  Gene Symbol: LSP1
  •  SwissProt: P33241
  •  Chromosome Location: 11p15.5
  •  Unigene: 56729
NBT03042