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Home >> Antibodies >> LH, alpha (Luteinizing Hormone, alpha)

LH, alpha (Luteinizing Hormone, alpha)

Mouse Monoclonal Antibody [Clone LHa/756]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Pituitary stained with LH alpha Mouse Monoclonal Antibody (LHa/756).

Product Details

Synonyms

Chorionic Gonadotrophin Alpha (CGA); Follicle Stimulating Hormone Alpha (FSHA); Follitropin Alpha; GPH Alpha; GPHA1; LH-alpha; Luteinizing Hormone Alpha (LHA); Lutropin Alpha; Thyroid Stimulating Hormone Alpha (TSHA); Thyrotropin Alpha;

Positive Control

Anterior Pituitary.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(No special pre-treatment is required for staining of formalin-fixed tissues. Note that HIER is NOT recommended for this antibody.)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length hLH alpha protein

Cellular Localization

Cytoplasmic, secreted

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~13kDa

Specificity & Comments

This MAb reacts with a protein of ~13kDa, identified as alpha sub-unit of Luteinizing Hormone (LH). Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Couzinet, B., et al. 1993. The control of gonadotrophin secretion by ovarian steroids. Hum. Reprod. 2: 97-101.

Bioinformatics

  •  Entrez Gene ID: 1081
  •  Gene Symbol: LHA
  •  SwissProt: P01215
  •  Chromosome Location: 6q12-q21
  •  Unigene: 119689
NBT00756