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Laminin Receptor/ RPSA (Marker of Metastatic Potential)

Recombinant Rabbit Monoclonal Antibody [Clone RPSA/6332R]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human pancreasstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human pancreasstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). HIER: Tris/EDTA, pH9.0, 45min. 2�: HRP-polymer, 30min. DAB, 5min.

Formalin-fixed, paraffin-embedded human colonstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). HIER: Tris/EDTA, pH9.0, 45min. 2�: HRP-polymer, 30min. DAB, 5min.

Formalin-fixed, paraffin-embedded human pancreasstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human pancreasstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). HIER: Tris/EDTA, pH9.0, 45min. 2�: HRP-polymer, 30min. DAB, 5min.

Formalin-fixed, paraffin-embedded human colonstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). HIER: Tris/EDTA, pH9.0, 45min. 2�: HRP-polymer, 30min. DAB, 5min.

Product Details

Synonyms

34/67kDa Laminin Receptor; 37kDa Laminin Receptor precursor; 37/67kDa Laminin Receptor; 37LRP; 40S Ribosomal Protein SA; 67kDa Laminin Receptor; 67LR; Colon Carcinoma Laminin-binding Protein; LAMBR; Laminin receptor 1; Laminin-binding Protein precursor p40; LAMR1; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; Ribosomal Protein SA (RPSA)

Positive Control

Human breast, colon or ovarian carcinoma.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human RPSA protein

Cellular Localization

Cell Surface,Cytoplasmic and Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

37-67kDa

Specificity & Comments

Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype.