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Home >> Antibodies >> Lambda Light Chain (B-Cell Marker)

Lambda Light Chain (B-Cell Marker)

Mouse Monoclonal Antibody [Clone ICO-106]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified Lambda Light Chain Mouse Monoclonal Antibody (ICO-106). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

Bence Jones Protein; BJP; IGLC 1/2/3; Mcg Marker; Paraprotein

Positive Control

293T, Raji or hPBL cells. Tonsil or Spleen.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA) Optimal dilution for a specific application should be determined.

Immunogen

Purified human IgG

Cellular Localization

Cell Surface, Cytoplasmic and Secreted

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~22.5kDa

Specificity & Comments

This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Martinova T.et al., In: Problems medical biotechnology and immunological infection diseases. Vol 11, 182-186, 1996.
  2. Baryshnikov A. et al., Gemat.Trasf. (Russian) N8, 4-7, 1990
  3. Baryshnikov A, and Tonevitsky A, Monoclonal antibodies in laboratory and clinic. Thesis p212, 1997.

Bioinformatics

NBT00019