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Home >> Antibodies >> Kappa Light Chain (B-Cell Marker)

Kappa Light Chain (B-Cell Marker)

Recombinant Mouse Monoclonal Antibody [Clone rKLC264]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Tonsil stained with Kappa Light Chain Mouse Recombinant Monoclonal Antibody (rKLC264).

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SDS-PAGE Analysis Kappa Light Chain Mouse Recombinant Monoclonal Antibody (rKLC264). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using Kappa Light Chain Mouse Monoclonal Antibody (rKLC/264)

Product Details

Synonyms

HCAK1; Ig Kappa Chain C Region; IGKC; Immunoglobulin KM

Positive Control

293T, Raji or hPBL cells. Tonsil or Spleen.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Ig kappa chain

Cellular Localization

Cell Surface, cytoplasmic and secreted

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~22.5kDa

Specificity & Comments

This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Takahashi H et. al. Pathol Res Prac 189:300-311 (1993).2. Momose H et. al. Hum Pathol. 23:1115-1119 (1992).

Bioinformatics

  •  Entrez Gene ID: 3514
  •  Gene Symbol: IGKC
  •  SwissProt: P01601, P01834
  •  Chromosome Location: 2p11.2
  •  Unigene: 449609
NBT02171