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Home >> Antibodies >> Kappa Light Chain (B-Cell Marker)

Kappa Light Chain (B-Cell Marker)

Mouse Monoclonal Antibody [Clone KLC264]

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

429.00

Formulation

Purified Ab conjugated to CF488

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab conjugated to CF488

Price (USD)

429.00

Product Details

Synonyms

HCAK1; Ig Kappa Chain C Region; IGKC; Immunoglobulin KM

Positive Control

293T, Raji or hPBL cells. Tonsil or Spleen.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Ig kappa chain

Cellular Localization

Cell Surface, cytoplasmic and secreted

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~22.5kDa

Specificity & Comments

This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

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Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

Key References

  1. Takahashi H et. al. Pathol Res Prac 189:300-311 (1993).2. Momose H et. al. Hum Pathol. 23:1115-1119 (1992).

Bioinformatics

  •  Entrez Gene ID: 3514
  •  Gene Symbol: IGKC
  •  SwissProt: P01601, P01834
  •  Chromosome Location: 2p11.2
  •  Unigene: 449609
NBT00264