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Home >> Antibodies >> Interleukin 10 (IL10) (Immuno-regulation Marker)

Interleukin 10 (IL10) (Immuno-regulation Marker)

Recombinant Rabbit Monoclonal Antibody [Clone IL10/2651R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human endo-cervical carcinoma stained with Interleukin 10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R).

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Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Interleukin 10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R).

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SDS-PAGE Analysis Purified IL-10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

Cytokine Synthesis Inhibitory Factor (CSIF); GVHDS; IL-10; IL10; IL10A; Interleukin-10; T-cell Growth Inhibitory Factor (TGIF)

Positive Control

Human adrenal or lymph node tissues (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human Interleukin 10 (IL10) protein

Cellular Localization

Cytoplasmic (secreted) and Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

20kDa (Monomer); 37kDa (Dimer)

Specificity & Comments

Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Related Products



200ug/ml of Ab Purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Bromberg, J.S. 1995. IL-10 immunosuppression in transplantation. Curr. Opin. Immunol. 7: 639-643.
  2. Fleming, S.D. and Campbell, P.A. 1996. Macrophages have cell surface IL-10 that regulates macrophage bactericidal activity. J. Immunol. 156: 1143-1150.

Bioinformatics

  •  Entrez Gene ID: 3586
  •  Gene Symbol: IL10
  •  SwissProt: P22301
  •  Chromosome Location: 1q32.1
  •  Unigene: 193717
NBT02651