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Home >> Antibodies >> Interferon alpha-1 (IFNA1)

Interferon alpha-1 (IFNA1)

Mouse Monoclonal Antibody [Clone 2-48]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified Interferon alpha-1 Mouse Monoclonal Antibody (2-48). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

IFN alpha; IFN alpha 1/13; IFN alpha 1b; Interferon alpha 13 (IFNA13); Interferon alpha leukocyte (IFL); Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); LeIF D

Positive Control

Stimulated human peripheral blood mononuclear cells.

Known Applications & Suggested Dilutions

Flow Cyt, Western Blot, IHC, IF         More Details

Flow Cytometry (1-2ug/million cells)
Western Blot (1-2ug/ml)
Immunohistochemistry (frozen)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Purified recombinant human IFN-alpha1

Cellular Localization

Cytoplasmic & Extracellular (Secreted)

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

16-27kDa

Specificity & Comments

This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Sen GC et al. J Biol Chem 1992, 267(8):5017-5020
  2. Pestka S et al. Annu Rev Biochem 1987, 56:727-777
  3. Capon DJ et al. Mol Cell Biol 1985, 5(4):768-779

Bioinformatics

  •  Entrez Gene ID: 3439
  •  Gene Symbol: IFNA1
  •  SwissProt: P01562
  •  Chromosome Location: 9q22
  •  Unigene: 37026, 533471
NBT00997