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Home >> Antibodies >> Insulin / IRDN (beta-Cell & Insulinoma Marker)

Insulin / IRDN (beta-Cell & Insulinoma Marker)

Recombinant Mouse Monoclonal Antibody [Clone rIRDN/805]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Pancreas stained with Insulin Mouse Recombinant Monoclonal Antibody (rIRDN/805).

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SDS-PAGE Analysis Purified Insulin Mouse Recombinant Monoclonal Antibody (rIRDN/805). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

IDDM2, ILPR, IRDN, MODY10, Proinsulin

Positive Control

MIA PaCa-2 cells. Pancreas.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human Insulin protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Cow. Pig. Rabbit. Mouse.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

6kDa

Specificity & Comments

Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Rajagopal, J., et al. 2003. Science 299: 363.
  2. de la Tour, D., et al. 2001. Mol. Endoc. 15: 476-483.
  3. Morisset, J., et al. 2003. J. Histochem. Cytochem. 51: 1501-1513.

Bioinformatics

  •  Entrez Gene ID: 3630
  •  Gene Symbol: INS
  •  SwissProt: P01308
  •  Chromosome Location: 11p15.5
  •  Unigene: 272259
NBT01979