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Home >> Antibodies >> IL3RA / CD123 (Acute Myeloid Leukemia Marker)

IL3RA / CD123 (Acute Myeloid Leukemia Marker)

Mouse Monoclonal Antibody [Clone IL3RA/1531]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Tonsil stained with IL3RA/CD123 Mouse Monoclonal Antibody (IL3RA/1531).

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Formalin-fixed, paraffin-embedded human Lymph Node stained with IL3RA/CD123 Mouse Monoclonal Antibody (IL3RA/1531).

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Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with IL3RA/CD123 Mouse Monoclonal Antibody (IL3RA/1531).

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SDS-PAGE Analysis Purified IL3RA/CD123 Mouse Monoclonal Antibody (IL3RA/1531). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using CD123 Mouse Monoclonal Antibody (IL3RA/1531)

Product Details

Synonyms

CD123; hIL3Ra; IL-3R-alpha; IL-3RA; IL3RAX; IL3RAY; IL3RX; IL3RY; Interleukin-3 Receptor, alpha; Interleukin3 receptor; Interleukin3 receptor, Y-chromosomal

Positive Control

THP-1, RPMI-8226 or HDLM-2 cells. Tonsil, Lymph Node or Stomach.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human IL3RA protein (around aa 26-171) (exact sequence is proprietary)

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

~70kDa

Specificity & Comments

CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudo-autosomal region on chromosomes X or Y.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Rollins-Raval M, Pillai R, Warita K, Mitsuhashi-Warita T, Mehta R, Boyiadzis M, Djokic M, Kant JA, Roth CG. CD123 immunohistochemical expression in acute myeloid leukemia is associated with underlying FLT3-ITD and NPM1 mutations. Appl Immunohistochem Mol Morphol. 2013 May;21(3):212-7.

Bioinformatics

  •  Entrez Gene ID: 3563
  •  Gene Symbol: IL3RA
  •  SwissProt: P26951
  •  Chromosome Location: Xp22.3 or Yp11.3
  •  Unigene: 632790
NBT01531