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Home >> Antibodies >> IgM (Immunoglobulin MuHeavy Chain) (B-Cell Marker)

IgM (Immunoglobulin MuHeavy Chain) (B-Cell Marker)

Recombinant Rabbit Monoclonal Antibody [Clone IGHM/2559R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Tonsil stained with IgMRabbit Recombinant Monoclonal Antibody (IGHM/2559R).

img

SDS-PAGE Analysis Purified IgM Rabbit Recombinant Monoclonal Antibody (IGHM/2559R). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

AGM1; IGHM; Constant Region of Heavy Chain of IgM; Ig Mu Chain C Region

Positive Control

293T, Raji or hPBL cells. Tonsil or Spleen.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Heavy chain of human IgM

Cellular Localization

Cytoplasm, Cell Surface and Secreted

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

50-75kDa

Specificity & Comments

Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Martinova T.et al., In: Problems medical biotechnology and immunological infection diseases. Vol 11, 182-186, 1996.
  2. Baryshnikov AIu. Gematol Transfuziol. 1990 Aug;35(8):4-7.

Bioinformatics

  •  Entrez Gene ID: 3507
  •  Gene Symbol: IGHM
  •  SwissProt: P01871, P20769
  •  Chromosome Location: 14q32.33
  •  Unigene: 510635
NBT02559