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Home >> Antibodies >> IGFBP3

IGFBP3

Mouse Monoclonal Antibody [Clone IGFBP3/3517]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human placenta stained with IGFBP3 Mouse Monoclonal Antibody (IGFBP3/3517)at 2ug/ml in PBS. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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SDS-PAGE Analysis Purified IGFBP3 Mouse Monoclonal Antibody (IGFBP3/3517). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using IGFBP3 Monospecific Mouse Monoclonal Antibody (IGFBP3/3517).

Product Details

Synonyms

Acid stable subunit of the 140 K IGF complex; Binding protein 29; Binding protein 53; BP53; Growth hormone dependent binding protein; IBP3; IGF binding protein 3; IGFBP3; Insulin-like growth factor binding protein 3 precursor

Positive Control

Human placenta or lymph node.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-lengthIGFBP3protein

Cellular Localization

Secreted.Localized to vesicles, cytosol and nucleoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

40/44kDa

Specificity & Comments

The Insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Vassilieva, I., et al. 2020. Paracrine senescence of human endometrial mesenchymal stem cells: a role for the Insulin-like growth factor binding protein 3. Aging 12: 1987-2004.

Bioinformatics