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Home >> Antibodies >> Human Herpes Virus 8 (HHV8)

Human Herpes Virus 8 (HHV8)

Rat Monoclonal Antibody [Clone LN53]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified HHV8 Rat Monoclonal Antibody (LN53). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

HHV8; Human Herpes Virus 8; Human herpesvirus 8; Kaposi's sarcoma associated herpes virus; KSHV

Positive Control

Kaposi's sarcoma. Cultured cells infected with HHV8.

Known Applications & Suggested Dilutions

ELISA, IF, IHC-P         More Details

ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant protein corresponding to the latent nuclear antigen 1 molecule of HHV8

Cellular Localization

Nuclear (virus in Kaposi's sarcoma)

Species Reactivity

Species independent

Host / Ig Isotype

Rat / IgG2c, kappa

Mol. Weight of Antigen

Not Known

Specificity & Comments

HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. HHV8 is associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. HHV 8 is the likely etiological agent of Kaposis sarcoma.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Dupin et al. Proc. Natl. Acad. Sci. USA 96: 4546, 1999.
  2. Ablashi et al. Clinc Microbiol Reviews 15: 439, 2002
  3. Kellam et al. J Virol 73: 5149, 1999.

Bioinformatics

NBT01746