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Home >> Antibodies >> HSV1 (Herpes Simplex Virus Type I) ICP8

HSV1 (Herpes Simplex Virus Type I) ICP8

Mouse Monoclonal Antibody [Clone HSVI/2045]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified HSVI Mouse Monoclonal Antibody (HSVI/2045). Confirmation of Integrity and Purity

Product Details

Synonyms

HSV1; Herpes simplex virus 1

Positive Control

HSV1 infected cells. Tissue.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Baculovirus-expressed HSV DNA polymerase (POL) and POL/UL42 complex

Cellular Localization

Cytoplasmic and/or Nuclear

Species Reactivity

HSV1 (Herpes Simplex Virus 1)

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

150kDa

Specificity & Comments

The antibody reacts with HSV type 1 specific antigen. It is suitable for detection of HSV in human cellular material obtained from superficial lesions or biopsies and for the early identification of HSV in infected tissue cultures. The herpes simplex virus (HSV) (also known as cold sore, night fever or fever blister) is a virus that causes a contagious disease. There are two main types of Herpes Simplex Virus (HSV), 1 and 2. The HSV-1 strain generally appears in the orafacial organs. HSV2 usually resides in the sacral ganglion at the base of the spine. All herpes viruses are morphologically identical: they have a large double-stranded DNA genome and the virion consists of an icosahedral nucleo-capsid, which is surrounded by a lipid bilayer envelope. ICP8, the HSV1 encoded single-strand DNA (ssDNA)-binding protein, is the major DNA binding protein of HSV1. ICP8 promotes single-stranded DNA to assemble into a homologous duplex plasmid producing a displacement loop. At higher concentrations, however, ICP8 facilitates the reverse reaction due to its helix destabilizing activity.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Boehmer, P.E. 1998. The herpes simplex virus type-1 single-strand DNAbinding protein, ICP8, increases the processivity of the UL9 protein DNA helicase. J. Biol. Chem. 273: 2676-2683.
  2. White, E.J. and Boehmer, P.E. 1999. Photoaffinity labeling of the herpes simplex virus type-1 single-strand DNA-binding protein (ICP8) with oligodeoxyribonucleotides. Biochem. Biophys. Res. Commun. 264: 493-497

Bioinformatics

NBT02045