Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with HSP60 Monoclonal Antibody (GROEL/730)
Formalin-fixed, paraffin-embedded human Tonsil stained with HSP60 Monoclonal Antibody (GROEL/730
Formalin-fixed, paraffin-embedded human Pancreas stained with HSP60 Monoclonal Antibody (GROEL/730).
Western Blot Analysis of HeLa cell lysate using HSP60 Monoclonal Antibody (GROEL/730).
Confocal immunofluorescence image of HeLa cells using HSP60 Monoclonal Antibody (GROEL/730). Green (CF488) and Reddot is used to label the nuclei Red.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a 60kDa protein, identified as the heat shock protein 60 (hsp60). A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (hsp's), more appropriately called as stress response proteins (srp's). Hsp60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial hsp60, but also against its mammalian homolog. Clone GROEL730 reacts only with human and is useful in distinguishing human hsp60 from other mammalian and bacterial hsp60.