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Home >> Antibodies >> HPV-18 (Human Papilloma Virus 18)

HPV-18 (Human Papilloma Virus 18)

Mouse Monoclonal Antibody [Clone HPV18/1297]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV18/1297).

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Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV18/1297).

Product Details

Synonyms

E6; Human Papilloma Virus; HPV type 18 E6; Protein E6

Positive Control

HPV-18 infected cells. Cervical tissue.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

HPV18 E6-β-galactosidase fusion protein

Cellular Localization

Nuclear

Species Reactivity

Type 18 of Human Papilloma Virus (HPV-18)

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

16kDa

Specificity & Comments

Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Reich, N.C., et al. 1983. Mol. Cell. Biol. 3: 2143-2150.

Bioinformatics

NBT01297