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Home >> Antibodies >> HLA-G (Major Histocompatibility Complex, class I, G)

HLA-G (Major Histocompatibility Complex, class I, G)

Recombinant Rabbit Monoclonal Antibody [Clone HLAG/8393R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified HLA-G Recombinant Rabbit Monoclonal Antibody (HLAG/8393R). Confirmation of Purity and Integrity of Antibody.

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Formalin-fixed, paraffin-embedded human placenta stained with HLA-G Recombinant Rabbit Monoclonal Antibody (HLAG/8393R). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

Product Details

Synonyms

B2 microglobulin; DADB-15K14.8; HLA 6.0; HLA G histocompatibility antigen class I G; HLA G3; HLA60; HLAG; Major histocompatibility complex class I G; MHC class I antigen G; MHC G; T-cell A locus; TCA

Positive Control

Raji cells. Expressed in trophoblasts.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Purified His-tagged HLA-G protein.

Cellular Localization

Cell surface.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

39kDa

Specificity & Comments

Major histocompatibility complex (MHC), human leukocyte antigen (HLA) molecules are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an a or heavy chain, and a non-covalently associated protein, β2-microglobulin. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a noncovalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Babusikova O., et al. Neoplasma, 1985, 32(6):657-62.

Bioinformatics

  •  Entrez Gene ID: 3135
  •  Gene Symbol: HLA-G
  •  SwissProt: P17693
  •  Chromosome Location: 6p22.1
  •  Unigene: 512152