Formalin-fixed, paraffin-embedded human Lung Tumor stained with HLA-DR Mouse Monoclonal Antibody (TAL 1B5).
Flow Cytometric Analysis of Raji cells. HLA-DR Mouse Monoclonal Antibody (TAL 1B5) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).
Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with HLA-DR Mouse Monoclonal Antibody (TAL 1B5).
SDS-PAGE Analysis Purified HLA-DR Mouse Monoclonal Antibody (TAL 1B5). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Ramos cell lysates using HLA-DR Mouse Monoclonal Antibody (TAL 1B5).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC class II/ dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the sub- sequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain ( -Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.