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Home >> Antibodies >> HLA-ABC (MHC I)

HLA-ABC (MHC I)

Mouse Monoclonal Antibody [Clone 246-B8.E7]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified HLA-ABC Mouse Monoclonal Antibody (246-B8.E7). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

HLA-A; HLA-B; HLA-C; HLA class 1A; HLA class 1B; HLA class 1C; Major histocompatibility complex, class I, A + B + C; MHC class I HLA-A; MHC class I HLA-B; MHC class I HLA-C; MHC HLA-ABC

Positive Control

THP-1 and Jurkat cells. Tonsil or lymph node.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human peripheral blood leukocytes

Cellular Localization

Cell surface

Species Reactivity

Human. Mouse. Non-Human primates.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

~41kDa

Specificity & Comments

Reacts with a monomorphic determinant of human major histocompatibility (MHC) class I antigens (HLA-A, B and C). Human MHC class I antigens are expressed constitutively on all nucleated cells lymphocytes such as lymphocytes, thymocytes, granulocytes, and bone marrow cells and are absent on erythrocytes. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Young NT et al. Killer cell inhibitory receptor interactions with HLA class I molecules: implications for alloreactivity and transplantation. Hum Immunol 1997, 52(1):1-11
  2. Krensky AM et al Immunomodulation by HLA class I-derived peptides. Transplant Proc 1996, 28(6):3026-8
  3. Hansen JA et al The HLA system in clinical marrow transplantation. Hematol Oncol Clin North Am 1990, 4(3):507-515.

Bioinformatics

NBT01054