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Home >> Antibodies >> HER-2 / c-erbB-2 / neu / CD340

HER-2 / c-erbB-2 / neu / CD340

Mouse Monoclonal Antibody [Clone SPM172]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with HER-2 Mouse Monoclonal Antibody (SPM172).

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SDS-PAGE Analysis Purified HER-2 Mouse Monoclonal Antibody (SPM172). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

p185, CD340, Verb b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog

Positive Control

SKBR-3 cells. Breast Cancers.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human HER-2 protein fragment (around aa 311-462) (exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG, kappa

Mol. Weight of Antigen

185kDa

Specificity & Comments

Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Wright C, et al. British Journal of Cancer. 65: 118-121 (1992).
  2. Utrilla JC, et al. Histopathology. 34: 60-65 (1999).
  3. Corbett IP, et al. Journal of Pathology. 161: 15-25 (1990).

Bioinformatics

  •  Entrez Gene ID: 2064
  •  Gene Symbol: ERBB2
  •  SwissProt: P04626
  •  Chromosome Location: 17q12
  •  Unigene: 446352
NBT02452