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Home >> Antibodies >> HER-2 / c-erbB-2 / neu / CD340

HER-2 / c-erbB-2 / neu / CD340

Mouse Monoclonal Antibody [Clone HRB2/258]

Catalog #


0.5 ml at 100ug/ml

Price (USD)



Purified Ab conjugated to CF488

Catalog No


0.5 ml at 100ug/ml


Purified Ab conjugated to CF488

Price (USD)


Product Details


p185, CD340, Verb b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog

Positive Control

SKBR-3 cells. Breast Cancers.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100)
Optimal dilution for a specific application should be determined.


Recombinant extracellular domain of human HER-2 protein

Cellular Localization

Cell Surface

Species Reactivity

Human. Rat.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen


Specificity & Comments

Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. C-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

Related Products

Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

Key References

  1. Wright C, et al. British Journal of Cancer. 65: 118-121 (1992).
  2. Utrilla JC, et al. Histopathology. 34: 60-65 (1999).
  3. Corbett IP, et al. Journal of Pathology. 161: 15-25 (1990).


  •  Entrez Gene ID: 2064
  •  Gene Symbol: ERBB2
  •  SwissProt: P04626
  •  Chromosome Location: 17q12
  •  Unigene: 446352