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Home >> Antibodies >> Guanine nucleotide-binding protein alpha-q / GNAQ / G-ALPHA-q

Guanine nucleotide-binding protein alpha-q / GNAQ / G-ALPHA-q

Mouse Monoclonal Antibody [Clone GNAQ/2434]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified GNAQ Mouse Monoclonal Antibody (GNAQ/2434). Confirmation of Integrity and Purity of the Antibody.

Product Details

Synonyms

CMC1; G alpha Q; G protein alpha Q; GAQ; guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding protein G(q) subunit alpha; SWS

Positive Control

HL-60, MOLT-4 and MCF-7 cells. Predominantly expressed in ovary, prostate, testis and colon.

Known Applications & Suggested Dilutions

ELISA, Flow Cyt, IF         More Details

ELISA (For coating, order Ab without BSA)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human GNAQ protein

Cellular Localization

Cytoplasmic and Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

45kDa

Specificity & Comments

GNAQis 359 amino acids long and is identical in all but 1 amino acid residue to the Mouse protein. Analysis of human genomic DNA revealed an intronless sequence with strong homology to human GNAQ cDNA. In comparison to GNAQ cDNA, this genomic DNA sequence included several small deletions and insertions that altered the reading frame, multiple single based changes, and a premature termination codon in the open reading frame, all hallmarks of a processed pseudogene. Probes derived from human GNAQ cDNA sequence mapped both chromosomes 2 and 9 in higher constringency genomic blot analyses of DNA from a panel of human/rodent hybrid cell lines.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Strathmann, M. and Simon, M.I. 1990. Proc. Natl. Acad. Sci. USA 87: 9113-9117.
  2. Simon, M.I., et al. 1991. Diversity of G proteins in signal transduction. Science 252: 802-808.
  3. Chen, B., et al. 1996. Biochim. Biophys. Acta 1281:125-128

Bioinformatics

  •  Entrez Gene ID: 2776
  •  Gene Symbol: GNAQ
  •  SwissProt: P50148
  •  Chromosome Location: 9q21.2
  •  Unigene: 269782
NBT02434