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Home >> Antibodies >> GPN1 / XAB1 (DNA Repair & Protein Synthesis)

GPN1 / XAB1 (DNA Repair & Protein Synthesis)

Mouse Monoclonal Antibody [Clone GPN1/2350]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Analysis of Protein Array containing more than 19,000 full-length human proteins using GPN1 Mouse Monoclonal Antibody (GPN1/2350)

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SDS-PAGE Analysis Purified GPN1 Mouse Monoclonal Antibody (GPN1/2350). Confirmation of Purity and Integrity of Antibody.

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Western Blot Analysis of human Brain tissue lysate using GPN1 Mouse Monoclonal Antibody (GPN1/2350).

Product Details

Synonyms

ATP(GTP) binding protein (ATPBD1A); GPN-loop GTPase 1; GPN1; MBD2-interacting protein (MBDin); NTPBP; RNA polymerase II associated protein 4 (RPAP4); XPA-binding protein 1 (XAB1) GTPase

Positive Control

Pancreas, Testis, Thyroid or Bladder.

Known Applications & Suggested Dilutions

ELISA, Western Blot         More Details

ELISA (For coating, order antibody without BSA)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human GPN1 protein

Cellular Localization

Cytoplasmic & Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

42kDa

Specificity & Comments

GPN1 is involved in protein synthesis events. It is expressed ubiquitously with highest expression in testis. It binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, GPN1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/ scaffolding activities. In addition, GPN1 interacts with components of the integrator and molecular chaperone complexes, further implicating GPN1 in protein assembly. GPN1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that GPN1 has possible GTPase activity.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Nitta, M., et al. 2000. A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. Nucleic Acids Res. 28: 4212-4218.

Bioinformatics

  •  Entrez Gene ID: 11321
  •  Gene Symbol: GPN1
  •  SwissProt: Q9HN4
  •  Chromosome Location: 2p23.3
  •  Unigene: 18259
NBT02350