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Home >> Antibodies >> GITR / Tnfrsf18 (Mouse)

GITR / Tnfrsf18 (Mouse)

Rat Monoclonal Antibody [Clone DTA-1]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified GITR Mouse Monoclonal Antibody (DTA-1). Confirmation of Purity and Integrity of Antibody

Product Details

Synonyms

Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18

Positive Control

CD25+CD4+Tregs.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Mouse CD25+ CD4+ T cells

Cellular Localization

Secreted & Cell surface

Species Reactivity

Mouse.

Host / Ig Isotype

Rat / IgG2b, lambda

Mol. Weight of Antigen

66-70kDa (Homodimer)

Specificity & Comments

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25+CD4+Tregs. In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Stephens GL, et al. 2004. J. Immunol. 173:5008.
  2. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059.

Bioinformatics

  •  Entrez Gene ID: 21936
  •  SwissProt: O35714
  •  Chromosome Location: 4; 4E (Mouse)
  •  Unigene: 3180
NBT00976