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Home >> Antibodies >> Galectin-1 / Human Placental Lactogen (hPL)

Galectin-1 / Human Placental Lactogen (hPL)

Recombinant Rabbit Monoclonal Antibody [Clone GAL1/2499R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Galectin-1 Monospecific Recombinant Rabbit Monoclonal Antibody (GAL1/2499R).

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SDS-PAGE Analysis Purified Galectin-1 Monospecific Recombinant Rabbit Monoclonal Antibody (GAL1/2499R). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Galectin-1 Monospecific Recombinant Rabbit Monoclonal Antibody (GAL1/2499R)

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Western Blot Analysis of JEG-3 and K562 cell lysate using Galectin-1 Monospecific Recombinant Rabbit Monoclonal Antibody (GAL1/2499R).

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Western Blot Analysis of HeLa cell lysate using Galectin-1 Monospecific Recombinant Rabbit Monoclonal Antibody (GAL1/2499R).

Product Details

Synonyms

14kDa laminin-binding protein; Beta-galactoside-binding lectin L-14-I; Gal-1; GAL1; Galaptin; Galectin-1; HLBP14; HPL; Lactose-binding lectin 1; Lect14; Lectin galactoside-binding soluble 1; LGALS1; MAPK activating protein MP12; S-Lac lectin 1

Positive Control

JEG-3, HeLa, K562 or 293 cells. Prostate, Kidney, Placenta, Stomach, Skin, Spleen, Brain or Heart.

Known Applications & Suggested Dilutions

Western Blot, ELISA, IHC-P         More Details

Western Blot (1-2ug/ml)
ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 12-108) of human Galectin-1 protein (exact sequence is proprietary)

Cellular Localization

Secreted (extracellular matrix)

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

14kDa

Specificity & Comments

Galectin-1 is a member of the beta-galactoside-binding family and is a dimeric protein of 14kD participating in a variety of normal and pathological processes, including cancer progression. Galectin-1 can affect the proliferation of normal and malignant cells. Inhibition of cell growth is observed in a lactose-dependent manner as lower concentrations of the lectin stimulate cell proliferation. Galectin-1 may also be implicated in the induction of apoptosis of activated T cells through the binding of exogenous galectin-1 to CD45 molecules present on the surface of lymphocytes. Galectin-1, reported to be present either at the surface of cancer cells or accumulated around these cells could act as an immunological shield to protect against a T cell immune response and provide an advantage for survival.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Couraud, P.O., et al. 1989. Molecular cloning, characterization, and expression of a human 14 kDa lectin. J. Biol. Chem. 264: 1310-1316.

Bioinformatics

  •  Entrez Gene ID: 3956
  •  Gene Symbol: LGALS1
  •  SwissProt: P09382
  •  Chromosome Location: 22q13.1
  •  Unigene: 445351
NBT02499