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Home >> Antibodies >> FOLH1 / PSMA (Prostate Epithelial Marker)

FOLH1 / PSMA (Prostate Epithelial Marker)

Mouse Monoclonal Antibody [Clone SPM500]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with FOLH1 (PSMA) Mouse Monoclonal Antibody (SPM500).

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SDS-PAGE Analysis Purified FOLH1 (PSMA) Mouse Monoclonal Antibody (SPM500). Confirmation of Integrity and Purity of Antibody.

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Western Blot Analysis of human LNCaP cell lysate using FOLH1 (PSMA) Mouse Monoclonal Antibody (SPM500).

Product Details

Synonyms

Cell growth-inhibiting gene 27 protein (GIG27); Folate hydrolase 1 (FOLH1); Folylpoly-gamma-glutamate carboxypeptidase (FGCP); Glutamate carboxylase II (GCPII); Glutamate carboxypeptidase 2 (GCP2); Glutamate carboxypeptidase II Membrane glutamate carboxypeptidase N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1 or NAALADase); Prostate-specific membrane antigen (PSM or PSMA); Pteroylpoly-gamma-glutamate carboxypeptidase

Positive Control

LNCap or HepG2 cells. Prostate Carcinoma.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human FOLH1 protein fragment (around aa 232-433) (exact sequence is proprietary)

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

100kDa

Specificity & Comments

Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. FOLH1 has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Israeli, R.S., et al. 1993. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res. 53: 227-230.

Bioinformatics

  •  Entrez Gene ID: 2346
  •  Gene Symbol: FOLH1
  •  SwissProt: Q04609
  •  Chromosome Location: 11p11.12
  •  Unigene: 654487
NBT02363