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Home >> Antibodies >> FCGRT / FcRn (IgG Transporter)

FCGRT / FcRn (IgG Transporter)

Mouse Monoclonal Antibody [Clone FCGRT/2932]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Cerebellum stained with FCGRT Mouse Monoclonal Antibody (FCGRT/2932).

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Formalin-fixed, paraffin-embedded human Testicular Cancer stained with FCGRT Mouse Monoclonal Antibody (FCGRT/2932).

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SDS-PAGE Analysis Purified FCGRT Mouse Monoclonal Antibody (FCGRT/2932). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using FCGRT Mouse Monoclonal Antibody (FCGRT/2932)

Product Details

Synonyms

Fc fragment of IgG, receptor transporter, alpha; FCGRT; FCRN, alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; Immunoglobulin receptor, intestinal, heavy chain; Neonatal Fc receptor

Positive Control

THP1 or HepG2 cells. Cerebellum or Testis.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human FCGRT protein (around aa 24-215) (Exact sequence is proprietary)

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

46kDa

Specificity & Comments

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kristi Baker et. al. Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer. Immunity 39 (6); 2013; 1095-1107.

Bioinformatics

  •  Entrez Gene ID: 2217
  •  Gene Symbol: FCGRT
  •  SwissProt: P55899
  •  Chromosome Location: 19q13.33
  •  Unigene: 111903
NBT02932