Formalin-fixed, paraffin-embedded human Breast Cancer stained with FAF1 Mouse Monoclonal Antibody (CPTC-FAF1-2).
SDS-PAGE Analysis Purified FAF1 Mouse Monoclonal Antibody (CPTC-FAF1-2). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with FAF1 Mouse Monoclonal Antibody (CPTC-FAF1-2).
Western Blot Analysis of HEK293, HeLa, MCF-7 cell lysates using Purified FAF1 Mouse Monoclonal Antibody (CPTC-FAF1-2).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Fas (TNFRSF6) associated factor 1 Monoclonal Antibody (CPTC-FAF1-2).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved 'death domain' and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions, while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1, for FAS-associated protein factor-1, binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells, FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD, FADD and RIP, FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation.