Formalin-fixed, paraffin-embedded human Placenta stained with Ezrin Mouse Monoclonal Antibody (CPTC-Ezrin-1).
Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Ezrin Mouse Monoclonal Antibody (CPTC-Ezrin-1).
SDS-PAGE Analysis Purified Ezrin Mouse Monoclonal Antibody (CPTC-Ezrin-1). Confirmation of Purity and Integrity of Antibody
Western Blot Analysis of SKBr-3, HeLa, HEK293, MCF-7 cell lysates using Ezrin Mouse Monoclonal Antibody (CPTC-Ezrin-1).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Ezrin / p81 Mouse Monoclonal Antibody (CPTC-Ezrin-1).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Ezrin, Moesin and Radixin belong to a family of highly homologous actin-associated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are co-expressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation. Overexpression of Ezrin predicts the poor prognosis of gastric adenocarcinoma.