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Home >> Antibodies >> ETS1 (Marker of Tumor Metastasis)

ETS1 (Marker of Tumor Metastasis)

Mouse Monoclonal Antibody [Clone ETS1/1801]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified ETS1 Mouse Monoclonal Antibody (ETS1/1801). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using ETS1 Mouse Monoclonal Antibody (ETS1/1801)

Product Details

Synonyms

Avian erythroblastosis virus E26 (v ets) oncogene homolog 1; ETS1; EWSR2; p54; v-ets erythroblastosis virus E26 oncogene homolog 1

Positive Control

HepG2 and HeLa cells. Tonsil, Skin, Pancreas, Kidney and Lymphoma.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human ETS1 fragment (around aa137-230) (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

54kDa

Specificity & Comments

ETS1 proto-oncogene is an important transcription factor that plays a role in cell proliferation and differentiation. ETS1 is related to the growth of carcinoma cells by its regulation of the transcription of matrix metalloproteinases and urokinase-type plasminogen activator.The processes of tumor invasion and metastasis depend on the increased proteolytic activity of the invading tumor cells that may involve matrix metalloproteinases, cathepsins B and D and plasminogen activator in the metastatic cascade. ETS1 is preferentially expressed in lymphoid cells, where it is essential for the maintenance of the normal pool of resting T and B cells.ETS1 expression level and distribution are differentially controlled in resting, activated and apoptotic lymphocytes.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Gaspar Kitange, et al. Immunohistochemical expression of Ets-1 transcription factor and the urokinase-type plasminogen activator is correlated with the malignant and invasive potential in meningiomas. Cancer 89 (11), 2292-2300, 2000.

Bioinformatics

  •  Entrez Gene ID: 2113
  •  Gene Symbol: ETS1
  •  SwissProt: P14921
  •  Chromosome Location: 11q23.3
  •  Unigene: 369438
NBT01801