2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> Estrogen Receptor, alpha (Marker of Estrogen Dependence)

Estrogen Receptor, alpha (Marker of Estrogen Dependence)

Mouse Monoclonal Antibody [Clone 1D5]

Catalog #

Size

0.1 ml
0.5 ml

Price (USD)

199.00
429

Formulation

Culture Supernatant
Culture Supernatant

Catalog No

Size

0.1 ml
0.5 ml

Formulation

Culture Supernatant
Culture Supernatant

Price (USD)

199.00
429
img

Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with Estrogen Receptor alpha Mouse Monoclonal Antibody (1D5).

Product Details

Synonyms

Estrogen Receptor alpha delta 4*5,6,7*/654 isoform; Estrogen Receptor alpha delta 4 +49 isoform; Nuclear receptor subfamily 3 group A member 1

Positive Control

MCF-7 cells. Breast or Endometrial Carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1:100-1:200 for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Estrogen Receptor alpha protein

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~67kDa

Specificity & Comments

This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.

Related Products



Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format.

Key References

  1. Zafrani B, et. al. Histopathology 2000; 37(6), 536-545.
  2. Harvey JM, et. al. Journal of Clinical Oncology 1999; 17(5), 1474-1481.

Bioinformatics

  •  Entrez Gene ID: 2099
  •  Gene Symbol: ESR1
  •  SwissProt: P03372
  •  Chromosome Location: 6q25.1
  •  Unigene: 208124
NBT01693