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Home >> Antibodies >> ER-beta-1 (Estrogen Receptor beta-1)

ER-beta-1 (Estrogen Receptor beta-1)

Mouse Monoclonal Antibody [Clone ERb455]

Catalog #


0.5 ml at 100ug/ml

Price (USD)



Purified Ab conjugated to CF488

Catalog No


0.5 ml at 100ug/ml


Purified Ab conjugated to CF488

Price (USD)


Flow Cytometry of human ER beta on BT474 cells. Black: cells alone; Grey: Isotype Control; Green: CF488-labeled ER beta Monoclonal Antibody (Erb455).

Product Details


Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 (ER beta), estrogen receptor beta 4

Positive Control

Ovarian, breast or prostate carcinoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100)
Optimal dilution for a specific application should be determined.


C-terminus fragment of recombinant human estrogen receptor beta protein

Cellular Localization

Predominantly nuclear

Species Reactivity

Human. Monkey. Mouse. Rat. Pig. Horse. Sheep.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen


Specificity & Comments

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Related Products

Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

Key References

  1. Skliris GP et. al. J Pathol 2002;197:155-62.


  •  Entrez Gene ID: 2100
  •  Gene Symbol: ESR2
  •  SwissProt: Q92731
  •  Chromosome Location: 14q23.2
  •  Unigene: 660607