Home >> Antibodies >> Endoglin / CD105 (Angiogenesis Marker)

Endoglin / CD105 (Angiogenesis Marker)

Mouse Monoclonal Antibody [Clone ENG/1621]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Immunofluorescent staining of PFA-fixed HeLa cells with Endoglin / CD105 Mouse Monoclonal Antibody (ENG/1621) followed by goat anti-mouse IgG-CF488 (Green).

Flow Cytometric Analysis of trypsinized PFA-fixed HeLa cells. Endoglin / CD105 Mouse Monoclonal Antibody (ENG/1621) followed by goat anti-mouse IgG-CF488 (Blue); Isotype control (Red).

SDS-PAGE Analysis Purified Endoglin / CD105 Mouse Monoclonal Antibody (ENG/1621).Confirmation of Integrity and Purity of Antibody.

Immunofluorescent staining of PFA-fixed HeLa cells with Endoglin / CD105 Mouse Monoclonal Antibody (ENG/1621) followed by goat anti-mouse IgG-CF488 (Green).

Flow Cytometric Analysis of trypsinized PFA-fixed HeLa cells. Endoglin / CD105 Mouse Monoclonal Antibody (ENG/1621) followed by goat anti-mouse IgG-CF488 (Blue); Isotype control (Red).

SDS-PAGE Analysis Purified Endoglin / CD105 Mouse Monoclonal Antibody (ENG/1621).Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

CD105; END; Endoglin; Eng; HHT1; S-endoglin

Positive Control

HeLa, A431 or HL-60 cells.

Known Applications & Suggested Dilutions

ELISA, Functional Assays, Flow Cyt, IF More Details

ELISA (For coating, order antibody without BSA)
Functional Assays (order antibody without BSA and azide)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (2-4ug/ml) Optimal dilution for a specific application should be determined.

Immunogen

Recombinant extracellular fragment of human Endoglin protein exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity

Human, Monkey, Horse, Pig and Rat.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

80kDa (Monomer); 160kDa (Homodimer)

Specificity & Comments

CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.