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Home >> Antibodies >> Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis)

Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis)

Mouse Monoclonal Antibody [Clone ELN/1981]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Small Intestine stained with Monospecific Mouse Monoclonal Antibody (ELN/1981) to Elastin.

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SDS-PAGE Analysis Purified Elastin Mouse Monoclonal Antibody (ELN/1981). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using Elastin (ELN) Mouse Monoclonal Antibody (ELN/1981)

Product Details

Synonyms

Elastin; ELN; SVAS; Tropoelastin; WBS; WS

Positive Control

A549 or U-2197 cells. Liver, Kidney, Lung or Intestine.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (For coating, order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human Elastin protein

Cellular Localization

Secreted and Extracellular Space

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

70kDa

Specificity & Comments

Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries.It is synthesized and secreted as a soluble, single-chain protein (tropoelastin), which undergoes a number of post-translational modifications prior to its organization into an elastic fiber in the extracellular space. Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. It imparts elasticityto the connective tissue. During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. The abnormal accumulation of elastic tissue in blood vessels is found in atherosclerosis and hypertension.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Fazio, M.J., Mattei, M.G., Passage, E., Chu, M.L., Black, D., Solomon, E., Davidson, J.M. and Uitto, J. 1991. Human elastin gene: new evidence for localization to the long arm of chromosome 7. Am. J. Hum. Genet. 48: 696-703.

Bioinformatics

  •  Entrez Gene ID: 2006
  •  Gene Symbol: ELN
  •  SwissProt: P15502
  •  Chromosome Location: 7q11.23
  •  Unigene: 647061
NBT01981