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Home >> Antibodies >> DNMT1 / DNA Methyltransferase 1

DNMT1 / DNA Methyltransferase 1

Mouse Monoclonal Antibody [Clone DNMT1/2061]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Placenta stained with DNMT1 Mouse Monoclonal Antibody (DNMT1/2061).

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Formalin-fixed, paraffin-embedded human Tonsil stained with DNMT1 Mouse Monoclonal Antibody (DNMT1/2061).

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SDS-PAGE Analysis Purified DNMT1 Mouse Monoclonal Antibody (DNMT1/2061). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

ADCADN; AIM; CXXC-type zinc finger protein 9; CXXC9; DNA methyltransferase 1 (DNMT1); HSN1E; MCMT; Met1; MommeD2

Positive Control

Raji cells. Tonsil or Placenta.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human DNMT1 protein fragment (around aa 767-912) (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

184kDa

Specificity & Comments

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene. Gene 242: 407-41
  2. Bigey, P., Ramchandani, S., Theberge, J., Araujo, F.D. and Szyf, M. 2000.

Bioinformatics

  •  Entrez Gene ID: 1786
  •  Gene Symbol: DNMT1
  •  SwissProt: P26358
  •  Chromosome Location: 19p13.2
  •  Unigene: 202672
NBT02061