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Home >> Antibodies >> Desmin (Muscle Cell Marker)

Desmin (Muscle Cell Marker)

Mouse Monoclonal Antibody [Clone DES/1711]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

Formalin-fixed, paraffin-embedded human Uterus stained with Desmin Monoclonal Antibody (DES/1711)

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SDS-PAGE Analysis of Purified Desmin Monoclonal Antibody (DES/1711). Confirmation of Purity and Integrity of Antibody

Product Details

Synonyms

CMD1I; CSM1; CSM2; DES; Intermediate filament protein

Positive Control

SJRH30 cells. Uterus or Leiomyosarcoma.

Known Applications & Suggested Dilutions

IF, Flow Cyt, Western Blot, IHC-P         More Details

Immunofluorescence (1-2ug/ml)
Flow Cytometry (1-2ug/million cells)
Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human desmin protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Mouse. Rat. Hamster. Chicken.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

52kDa

Specificity & Comments

Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Li, Z.L., et al. 1989. Human Desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development. Gene 78: 243-254.

Bioinformatics

  •  Entrez Gene ID: 1674
  •  Gene Symbol: DES
  •  SwissProt: P17661
  •  Chromosome Location: 2q35
  •  Unigene: 594952
NBT01711