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Home >> Antibodies >> Decorin

Decorin

Recombinant Rabbit Monoclonal Antibody [Clone DCN/8760R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Decorin Rabbit Recombinant Monoclonal Antibody (DCN/8760R). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

img

SDS-PAGE Analysis Purified Decorin Rabbit Recombinant Monoclonal Antibody (DCN/8760R). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Bone proteoglycan II; CSCD; Dermatan sulphate proteoglycans II (DSPG2); PG40; PGII; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B

Positive Control

Human prostate or skin tissue (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Decorin protein fragment (around aa212-336) (exact sequence is proprietary)

Cellular Localization

Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

43kDa

Specificity & Comments

Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGF and is a direct or indirect negative modulator of TGF synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN- and TNF may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Mosmann TR, et al. Collagen and related research 5.1 (1985 Jan): 23-39.

Bioinformatics

  •  Entrez Gene ID: 1634
  •  Gene Symbol: DCN
  •  SwissProt: P07585Human
  •  Chromosome Location: 12q21.3
  •  Unigene: 728830