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Home >> Antibodies >> Cytokeratin, Basic (Type II or HMW) (Epithelial Marker)

Cytokeratin, Basic (Type II or HMW) (Epithelial Marker)

Recombinant Rabbit Monoclonal Antibody [Clone KRTH/1576R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin, HMW Rabbit Recombinant Monoclonal Antibody (KRTH/1576R).

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Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin, HMW Rabbit Recombinant Monoclonal Antibody (KRTH/1576R).

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SDS-PAGE Analysis Purified Cytokeratin, HMW Rabbit Recombinant Monoclonal Antibody (KRTH/1576R).

Product Details

Synonyms

KRT2B; KRT2P; HUMCYT2A; Keratin, type II Cytoskeletal 2 oral; K76; Keratin 2p (K2P); Keratin-76; Cytokeratin-2P (CK-2P; Type-II Keratin Kb9

Positive Control

Epithelial cells, Skin or Adenocarcinomas.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (0.25-0.5ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human KRT76 protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Expected to show broad species reactivity.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

52-67kDa

Specificity & Comments

This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

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200ug/ml of recombinant MAb Purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Woodock-Mitchell J et. al. Journal of Cell Biology 1982;95:580-8.
  2. Tseng SCG et. al. Cell 1982; 30361.

Bioinformatics

  •  Entrez Gene ID: 51350
  •  Gene Symbol: KRT76
  •  SwissProt: Q01546
  •  Chromosome Location: 12q13.13
  •  Unigene: 654392
NBT01576