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Home >> Antibodies >> Cytokeratin, Basic (Type II or HMW) (Epithelial Marker)

Cytokeratin, Basic (Type II or HMW) (Epithelial Marker)

Mouse Monoclonal Antibody [Clone KRTH/1076]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).

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Formalin-fixed, paraffin-embedded Rat Stomach stained with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).

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Formalin-fixed, paraffin-embedded Rat Oviduct with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).

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SDS-PAGE Analysis Purified Cytokeratin, HMW MAb (KRTH/1076). Confirmation of Purity and Integrity of Antibody.

Product Details

Positive Control

Skin, Adenocarcinomas.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human KRT76 protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Rat. Shows broad species reactivity.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8)

Specificity & Comments

This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Woodock-Mitchell J et. al. Journal of Cell Biology 1982;95:580-8.
  2. Tseng SCG et. al. Cell 1982; 30361.

Bioinformatics

  •  Entrez Gene ID: 51350
  •  Gene Symbol: KRT76
  •  SwissProt: Q01546
  •  Chromosome Location: 12q13.13
  •  Unigene: 654392
NBT01076