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Home >> Antibodies >> Cytokeratin 5 (KRT5) (Basal, Myoepithelial & Mesothelial Cell Marker)

Cytokeratin 5 (KRT5) (Basal, Myoepithelial & Mesothelial Cell Marker)

Mouse Monoclonal Antibody [Clone KRT5/3594]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Cytokeratin 5 Mouse Monoclonal Antibody (KRT5/3594).

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Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Cytokeratin 5 Mouse Monoclonal Antibody (KRT5/3594).

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Formalin-fixed, paraffin-embedded human cervical carcinoma stained with Cytokeratin 5 Mouse Monoclonal Antibody (KRT5/3594).

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Formalin-fixed, paraffin-embedded human pancreas stained with Cytokeratin 5 Mouse Monoclonal Antibody (KRT5/3594).

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SDS-PAGE Analysis Purified Cytokeratin 5 Mouse Monoclonal Antibody (KRT5/3594). Confirmation of Purity and Integrity of Antibody

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Cytokeratin 5 Mouse Monoclonal Antibody (KRT5/3594).

Product Details

Synonyms

58kDa Cytokeratin; DDD1; Epidermolysis Bullosa Simplex 2 (EBS2); Keratin 5; Keratin, Type II Cytoskeletal 5; Keratin-5; Type-II Cytoskeletal 5; Type-II keratin Kb5

Positive Control

MCF-7 or HeLa cells. Human tonsil, esophagus or bladder tissue (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 316-590) of human Cytokeratin 5 (KRT5) protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

58kDa

Specificity & Comments

This MAb recognizes a protein of 58kDa, which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Antibodies to KRT5 identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium.Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas express.Anti-KRT5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelia, and basal cells of the prostate are labeled with anti-KRT5.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Ordonez NG. Human Pathology. 2007; 38:1 16.

Bioinformatics

  •  Entrez Gene ID: 3852
  •  Gene Symbol: KRT5
  •  SwissProt: P13647
  •  Chromosome Location: 12q13.13
  •  Unigene: 433845