Formalin-fixed, paraffin-embedded human Colon stained with Cytokeratin 19 Rabbit Recombinant Monoclonal Antibody (KRT19/1959R).
SDS-PAGE Analysis of Purified Cytokeratin 19 Rabbit Recombinant Monoclonal Antibody (KRT19/1959R).
Western Blot Analysis of Hep-G2 cell lysate using Cytokeratin 19 Rabbit Recombinant Monoclonal Antibody (KRT19/1959R).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
This Ab reacts with the rod domain of human cytokeratin 19 (CK19), a polypeptide of 40kDa. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.