Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Cytokeratin 18 Mouse Monoclonal Antibody (SPM510).
SDS-PAGE Analysis Purified Cytokeratin 18 Mouse Monoclonal Antibody (SPM510). Confirmation of Integrity and Purity of Antibody
Flow Cytometric Analysis of trypsinized paraformaldehyde-fixed HeLa cells using Cytokeratin 18 Mouse Monoclonal Antibody (SPM510) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
This MAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.