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Home >> Antibodies >> Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker)

Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker)

Mouse Monoclonal Antibody [Clone KRT16/1714]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Tonsil stained with Cytokeratin 16 Mouse Monoclonal Antibody (KRT16/1714).

img

SDS-PAGE Analysis Purified Cytokeratin 16 Mouse Monoclonal Antibody (KRT16/1714). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

CK16; Cytokeratin-16; Focal non epidermolytic palmoplantar keratoderma (FNEPPK / NEPPK); K1CP; Keratin Type I Cytoskeletal 16; Keratin-16; KRT16A

Positive Control

HeLa cells. Tonsil, Skin. Bladder or Cervix.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment from the C-terminal of human Cytokeratin 16

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

48kDa

Specificity & Comments

Cytokeratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I Cytokeratins (Cytokeratins 9 to 23) and one type II Cytokeratins (keratins 1 to 8). The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in non-invasive breast carcinomas and normal breast tissue.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Wetzels et al. 1991. Am J Pathol. 138(3):751-63.
  2. Markey et al. 1992. Br J Dermatol. 126(2):154-60.
  3. Porter et al. 2000. Lab Invest. 80(11):1701-10.

Bioinformatics

  •  Entrez Gene ID: 3868
  •  Gene Symbol: KRT16
  •  SwissProt: P08779
  •  Chromosome Location: 17q21.2
  •  Unigene: 655160
NBT01714