Formalin-fixed, paraffin-embedded human Tonsil stained with Cystatin A Mouse Monoclonal Antibody (CSTA/2882).
Formalin-fixed, paraffin-embedded human Prostate stained with Cystatin A Mouse Monoclonal Antibody (CSTA/2882).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Cystatin A Mouse Monoclonal Antibody (CSTA/2882).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.