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Home >> Antibodies >> Cyclin A1

Cyclin A1

Mouse Monoclonal Antibody [Clone XLA1-3]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Western Blot Analysis of (1) HeLa (2) Jurkat and (3) MCF-7 cell lysates using Cyclin A1 Mouse Monoclonal Antibody (XLA1-3).

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SDS-PAGE Analysis Purified Cyclin A1 Mouse Monoclonal Antibody (XLA1-3). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

CCN1, CCNA, CCNA2, Cyclin A1

Positive Control

Very high levels in testis. Also found in myeloid leukemia cell lines. Xenopus laevis tissue lysate.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length Xenopus laevis Cyclin A1 protein

Cellular Localization

Nucleus.

Species Reactivity

Xenopus laevis

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

65kDa

Specificity & Comments

The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin-dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F, and retinoblastoma protein p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34. The antibody detects Xenopus cyclin A in blots. Cyclin A1 is the embryonic cyclin which is present in Xenopus eggs. This MAb only detects Xenopus Cyclin A1.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Parida, P.K., et al. 2018. Inhibition of cancer progression by a novel transstilbene derivative through disruption of microtubule dynamics, driving G2/M arrest, and p53-dependent apoptosis. Cell Death Dis. 9: 448.

Bioinformatics

  •  Gene Symbol: ccna1
  •  SwissProt: P18606
  •  Chromosome Location: Chr02 (Xenopus laevis)
  •  Unigene: 4267
NBT03049