Formalin-fixed, paraffin-embedded human Pancreas stained with Chromogranin A Rabbit Recombinant Monoclonal Antibody (CHGA/1815R).
SDS-PAGE Analysis Purified Chromogranin A Rabbit Recombinant Monoclonal Antibody (CHGA/1815R).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Chromogranin A Rabbit Recombinant Monoclonal Antibody (CHGA/1815R).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.