|Catalog No||Formulation||Size||Price (USD)|
|1080-MSM3-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|1080-MSM3-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|1080-MSM3-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||1080|
|Human Unigene||489786, 621460, 661104|
|Human Gene Symbol||CFTR|
|Human Chromosome Location||7q31.2|
|Synonyms||ABC35; ATP Binding Cassette Superfamily C Member 7 (ABCC7); cAMP-dependent chloride channel; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; Cystic Fibrosis Transmembrane Conductance Regulator; MRP7; TNR CFTR|
|Immunogen||Recombinant human CFTR fragment (aa258-385) (exact sequence is proprietary)|
|Host / Ig Isotype||Mouse / IgG2b|
|Mol. Weight of Antigen||165-170kDa|
|Cellular Localization||Cell Surface and Cytoplasmic|
|Species Reactivity||Human. Others not known.|
Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
MOLT-4 cells. Pancreas, Kidney or Placenta.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.