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Home >> Antibodies >> Cell Division Cycle 34 homolog

Cell Division Cycle 34 homolog

Mouse Monoclonal Antibody [Clone CPTC-CDC34-2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with CDC34 Mouse Monoclonal Antibody (CPTC-CDC34-2).

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Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with CDC34 Mouse Monoclonal Antibody (CPTC-CDC34-2).

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SDS-PAGE Analysis Purified CDC34 Mouse Monoclonal Antibody (CPTC-CDC34-2). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Cell Division Cycle 34 homolog Mouse Monoclonal Antibody (CPTC-CDC34-2).

Product Details

Synonyms

Cdc34; cell division cycle 34; UBC3; UBCH3; UBE2R1; Ubiquitin carrier protein; Ubiquitin conjugating enzyme E2 32 kDa complementing; Ubiquitin protein ligase R1; Ubiquitin conjugating enzyme E2-CDC34

Positive Control

293, K562, Jurkat cell lysates. Human small intestine.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-length CDC34 protein

Cellular Localization

Nucleus. Cytoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

34kDa

Specificity & Comments

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90. Cdc34, Cdc27 and Cdc16 function as ubiquitinconjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphasepromoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Gautier, J., et al. 1991. Cell 67: 197-211.

Bioinformatics

  •  Entrez Gene ID: 997
  •  Gene Symbol: CDC34
  •  SwissProt: P49427
  •  Chromosome Location: 19p13.3
  •  Unigene: 514997
NBT02267