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Home >> Antibodies >> CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker)

CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker)

Mouse Monoclonal Antibody [Clone CDX2/1690]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/1690).

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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/1690).

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SDS-PAGE Analysis Purified CDX2 Mouse Monoclonal Antibody (CDX2/1690). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using CDX2 Mouse Monoclonal Antibody (CDX2/1690)

Product Details

Synonyms

Caudal type homeobox 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX2

Positive Control

HT29 cells. Colon Carcinoma.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)
(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa150-249) of human CDX2 protein (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

40kDa

Specificity & Comments

The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoidsand is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma.However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Mallo, G.V., et al. 1998. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J. Biol. Chem. 273: 14030-14036.
  2. Silberg, D.G., et al. 2000. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 119: 961-971.

Bioinformatics

  •  Entrez Gene ID: 1045
  •  Gene Symbol: CDX2
  •  SwissProt: Q99626
  •  Chromosome Location: 13q12.2
  •  Unigene: 174249
NBT01690